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KMID : 0043320120350091567
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Archives of Pharmacal Research
2012 Volume.35 No. 9 p.1567 ~ p.1572
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New methymycin derivatives of Streptomyces venezuelae ATCC 15439 and their inhibitory effects on human T cell proliferation mediated by PMA/ionomycin
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Ding Rong
Tang Jinshan
Gao Hao
Li Ting
Zhou Hua
Liu Liang
Yao Xin Sheng
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Abstract
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Two new methymycin derivatives, 3′-demethylmethymycin (1) and 3′-demethyldeoxymethymycin (2), together with seven known ones (3?9), were obtained from the strain Streptomyces venezuelae ATCC 15439. Their structures were determined on the basis of IR, MS, 1D and 2D NMR data. In addition, the inhibitory effects of all the compounds on human T cell proliferation mediated by PMA/ionomycin were evaluated. The data suggested for the first time that methymycin derivatives have potential anti-inflammatory activity.
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KEYWORD
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Streptomyces venezuelae ATCC 15439, Methymycin derivatives, Anti-inflammatory activity, 12- and 14-membered macrolides
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